Prevention of Diabetic Neuropathy by Regulatable Expression of HSV-Mediated Erythropoietin
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چکیده
منابع مشابه
Regulatable Transgene Expression for Prevention of Chemotherapy-Induced Peripheral Neuropathy
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15 صفحه اولErythropoietin both protects from and reverses experimental diabetic neuropathy.
Erythropoietin (EPO) possesses generalized neuroprotective and neurotrophic actions. We tested the efficacy of recombinant human EPO (rhEPO) in preventing and reversing nerve dysfunction in streptozotocin (STZ)-induced diabetes in rats. Two days after STZ [60 mg/kg of body weight (b.w.), i.p.], diabetic animals were administered rhEPO (40 microg/kg of b.w.) three times weekly for 5 weeks either...
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ژورنال
عنوان ژورنال: Molecular Therapy
سال: 2011
ISSN: 1525-0016
DOI: 10.1038/mt.2010.215